cDNA sequence of the β2‐subunit of human liver alcohol dehydrogenase

A cDNA library of mRNA from a human liver expressing the β2‐subunit of alcohol dehydrogenase was constructed in λgt11. One clone coding for 352 of a total of 374 amino acid residues of the β2‐subunit was isolated. The sequence differed from that of the β1‐subunit at one nucleotide position resulting...

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Veröffentlicht in:	FEBS letters 1988-07, Vol.234 (1), p.53-55
Hauptverfasser:	Ehrig, Torsten, von Wartburg, Jean-Pierre, Wermuth, Bendicht
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol dehydrogenase Amino acid substitution Biological and medical sciences cDNA Fundamental and applied biological sciences. Psychology Genes. Genome Human liver Molecular and cellular biology Molecular genetics NAD+ binding site
Online-Zugang:	Volltext
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Zusammenfassung:	A cDNA library of mRNA from a human liver expressing the β2‐subunit of alcohol dehydrogenase was constructed in λgt11. One clone coding for 352 of a total of 374 amino acid residues of the β2‐subunit was isolated. The sequence differed from that of the β1‐subunit at one nucleotide position resulting in an Arg/His exchange at position 47 of the peptide chain, in agreement with data from protein sequence analysis [(1984) FEBS Lett. 173, 360–366].
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(88)81301-2