The influence of folic acid on the picrotoxin-sensitive site of the GABA a-receptor complex

The influence of folic acid on the picrotoxin-sensitive site of the GABA a-receptor complex

The site of action responsible for the convulsive effect of folic acid was investigated in vitro. Folic acid ( EC max 5 × 10 −4 M) enhances the binding of the cage convulsant [ 3H];-butylbicycioorthobenzoate ([ 3H]TBOB) to rat brain membranes, namely to 130% of control in the absence of GABA and to...

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Veröffentlicht in:Epilepsy research 1988, Vol.2 (3), p.215-218
Hauptverfasser: Van Rijn, C.M., Van der Velden, T.J.A.M., de Miranda, J.F.Rodrigues, Feenstra, M.G.P., Hommes, O.R.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cage convulsant
Epilepsy
Folic acid
GABA
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Receptor-binding
TBOB
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Zusammenfassung:The site of action responsible for the convulsive effect of folic acid was investigated in vitro. Folic acid ( EC max 5 × 10 −4 M) enhances the binding of the cage convulsant [ 3H];-butylbicycioorthobenzoate ([ 3H]TBOB) to rat brain membranes, namely to 130% of control in the absence of GABA and to over 300% of control in the presence of physiological concentrations of GABA. Analysis of the binding parameters reveals that folic acid increases the apparent number of [ 3H]TBOB binding sites.
ISSN:0920-1211
1872-6844
DOI:10.1016/0920-1211(88)90058-7