Evaluation of the acute dermal toxicity of a thermally decomposed military specification l-23699 synthetic aircraft lubricant

Abstract Acute dermal toxicity of pyrolyzed MIL-L-23699 lubricant samples was determined in male and female B6C3F1 mice. The lethal dose for 50% of the population (LD50) of male B6C3F1 mice was estimated to be approximately 50 mg/kg and for female mice approximately 100 mg/kg. The lethal effects of toxicity can be prevented if the exposure site is thoroughly washed and dried within 5 min after exposure. Tap water (deionized) or sea water worked just as well as a detergent wash in preventing the lethal aspects of the pyrolysate exposure to the skin. When comparing the solvent effects of the oil pyrolysate to dimethylsulfoxide (DMSO) as a vehicle for the penetration of the neurotoxicant formed in the pyrolysate, DMSO was a better vehicle, enhancing penetration of the neurotoxicant at least 20-fold.