Stress-Induced Alterations of Immunity in Hypophysectomized Rats

Stress-Induced Alterations of Immunity in Hypophysectomized Rats

Stress-induced suppression of mitogen-induced lymphocyte proliferation was demonstrated in hypophysectomized rats. Stress effects on the numbers of peripheral blood lymphocytes and lymphocyte subsets and on splenic natural killer cell activity require the presence of pituitary. A pituitary-dependent...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1988-12, Vol.85 (23), p.9297-9301
Hauptverfasser: Keller, Steven E., Schleifer, Steven J., Liotta, Anthony S., Bond, Ronald N., Farhoody, Nauder, Stein, Marvin
Format: Artikel
Sprache:eng
Schlagworte:
Adrenocorticotropic Hormone - blood
Animals
B-Lymphocytes - classification
B-Lymphocytes - immunology
beta-Endorphin - analysis
Biological and medical sciences
Blood
Blood plasma
Brain Chemistry
Control groups
Corticosterone - blood
Corticotropin-Releasing Hormone - analysis
Electroshock
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hypophysectomy
Immunity
Immunobiology
Lymphocyte Activation
Lymphocyte proliferation
Lymphocytes
Male
Modulation of the immune response (stimulation, suppression)
Natural killer cells
Rats
Rats, Inbred Strains
Reference Values
Spleen
Stress, Psychological - immunology
Stress, Psychological - physiopathology
T lymphocytes
T-Lymphocytes - immunology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Stress-induced suppression of mitogen-induced lymphocyte proliferation was demonstrated in hypophysectomized rats. Stress effects on the numbers of peripheral blood lymphocytes and lymphocyte subsets and on splenic natural killer cell activity require the presence of pituitary. A pituitary-dependent restraining influence on stress-induced alteration of immunity is described. These results indicate that stress-induced modulation of immunity is complex and includes a range of enhancing and inhibitory mechanisms.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.85.23.9297