Cu(II) catalyzed hydrolysis of an unactivated ester based on reversible conjugate addition

Cu(II) catalysis provides a 16,000-fold acceleration in the hydrolysis of methyl acrylate when a removable vicinal diamine ligand is used to increase the stability of the required copper chelate. Cu(II) provides a 16,000-fold acceleration in the hydrolysis of methyl acrylate when a removable ligand...

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Veröffentlicht in:	Tetrahedron letters 1989, Vol.30 (50), p.6951-6954
Hauptverfasser:	Duerr, Brook F., Czarnik, Anthony W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Kinetics and mechanisms Organic chemistry Reactivity and mechanisms
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Cu(II) catalysis provides a 16,000-fold acceleration in the hydrolysis of methyl acrylate when a removable vicinal diamine ligand is used to increase the stability of the required copper chelate. Cu(II) provides a 16,000-fold acceleration in the hydrolysis of methyl acrylate when a removable ligand is used to increase the stability of the required copper chelate. Metal ion catalysis, not promotion, is observed.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/S0040-4039(01)93395-7