Effectiveness and safety of a single intravenous Bolus injection of tissue-type plasminogen activator in acute myocardial infarction

The efficacy of multiple intravenous bolus injections of tissue-type plasminogen activator (t-PA) in inducing rapid coronary recanalization in patients with acute myocardial infarction was previously demonstrated. In this Bolus Dose-Escalation Study of Tissue-Type Plasminogen Activator (BEST), the e...

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Veröffentlicht in:	The American journal of cardiology 1992-06, Vol.69 (17), p.1393-1398
Hauptverfasser:	Hackett, David, Andreotti, Felicita, Haider, Agha W., Brunelli, Claudio, Shahi, Manjit, Fussell, Anne, Buller, Nigel, Foale, Rodney, Lipkin, David, Caponnetto, Salvatore, Davies, Graham, Maseri, Attilio, The Bolus Dose-Escalation Study of Tissue-Type Plasminogen Activator (BEST) Investigators
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Life Sciences & Biomedicine Medical sciences Pharmacology. Drug treatments Science & Technology
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Zusammenfassung:	The efficacy of multiple intravenous bolus injections of tissue-type plasminogen activator (t-PA) in inducing rapid coronary recanalization in patients with acute myocardial infarction was previously demonstrated. In this Bolus Dose-Escalation Study of Tissue-Type Plasminogen Activator (BEST), the efficacy of 3 different doses of a single rapid intravenous bolus injection of t-PA (duteplase, Wellcome Foundation, London) in inducing coronary patency (Thrombolysis In Myocardial Infarction perfusion grade 2 or 3) in 64 patients with acute myocardial infarction presenting
ISSN:	0002-9149 1879-1913
DOI:	10.1016/0002-9149(92)90888-6