A comparative study of mitotic delay and inhibition of transcription in cells exposed to UV and heat shock: the possible use of mitotic delay duration as a parameter for assaying extent of damage and recovery

We have evaluated percentage inhibition of transcription and extent of mitotic delay induced by ultraviolet irradiation and heat shock, either applied alone or in combination, employing the synchronously mitotic plasmodia of the myxomycete Physarum polycephalum as a model system. While percentage in...

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Veröffentlicht in:Current science (Bangalore) 1992-02, Vol.62 (3), p.314-316
Hauptverfasser: Kumar, P. R. Manish, Nair, Vimala R., née Devi
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Sprache:eng
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Zusammenfassung:We have evaluated percentage inhibition of transcription and extent of mitotic delay induced by ultraviolet irradiation and heat shock, either applied alone or in combination, employing the synchronously mitotic plasmodia of the myxomycete Physarum polycephalum as a model system. While percentage inhibition of transcription, estimated soon after the perturbations, is a good indicator of the extent of a specific kind of damage, the duration of mitotic delay serves also as a reliable parameter for evaluating the extent of overall damage and rate of recovery of the system. Interestingly, according to this criterion, recovery from the effect of radiation is faster if it is preceded by a pulse of hyperthermia.
ISSN:0011-3891