Microbiological synthesis of optically active (2R,3S)-2,3-deuteriocyclohexan-1-ones and (2R,3S)-2-methyl-3-deuteriocyclohexan-1-one. Enantiospecific anti-addition of hydrogen to the double bond of cyclohex-2-en-1-ones

Addition of hydrogen to the double bond of cyclohexenones during microbiological reduction by Beauveria sulfurescens gives the trans product in high yield (90%) resulting from anti-addition to the si face on C-2 and the re face on C-3. [Display omitted] [Display omitted] [Display omitted]