A new approach to encapsulating non-steroidal anti-inflammatory drugs. V. Biopharmaceutical study of microcapsules of azapropazone coated with pectin and rutin

Abstract Azapropazone was encapsulated with pectin-rutin mixture using the fluidized bed technique. The encapsulated particles showed higher dissolution rate and bioavailability but lower ulcerogenic activity as compared with the drug alone.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of microencapsulation 1992, Vol.9 (1), p.67-72
Hauptverfasser:	Meshali, M. M., El-Dien, E. Z., Omar, S. A., Luzzi, L. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apazone - administration & dosage Apazone - pharmacokinetics Apazone - toxicity Biological and medical sciences Biological Availability Digestive system Drug Compounding - methods Male Medical sciences Particle Size Pectins - chemistry Pharmacology. Drug treatments Rats Rutin - chemistry Stomach Ulcer - chemically induced
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Beschreibung
Zusammenfassung:	Abstract Azapropazone was encapsulated with pectin-rutin mixture using the fluidized bed technique. The encapsulated particles showed higher dissolution rate and bioavailability but lower ulcerogenic activity as compared with the drug alone.
ISSN:	0265-2048 1464-5246
DOI:	10.3109/02652049209021224