Characterization of Lex, Ley and A Ley antigen determinants in KDN‐containing O‐linked glycan chains from Pleurodeles waltlii jelly coat eggs
Novel acidic oligosaccharides were isolated in large amounts by reductive alkaline treatment of the jelly coat of Pleurodeles waltlii (Michah) eggs. The oligosaccharides were found to contain the newly described KDN as acidic monosaccharide and possess either the Lex, Ley and A Ley antigenic determi...
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| Veröffentlicht in: | FEBS letters 1992-02, Vol.298 (1), p.39-43 |
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| container_title | FEBS letters |
| container_volume | 298 |
| creator | Strecker, Gérard Wieruszeski, Jean-Michel Michalski, Jean-Claude Alonso, Catherine Boilly, Benoni Montreuil, Jean |
| description | Novel acidic oligosaccharides were isolated in large amounts by reductive alkaline treatment of the jelly coat of Pleurodeles waltlii (Michah) eggs. The oligosaccharides were found to contain the newly described KDN as acidic monosaccharide and possess either the Lex, Ley and A Ley antigenic determinants. Occurrence of Lex and Ley determinants previously recognized as tumor‐associated antigen (TAA) demonstrates that mucins of lower animals may represent a rich and easily available source for preparing TAA. Moreover, it reinforces the hypothesis according to which TAA are evolution markers. |
| doi_str_mv | 10.1016/0014-5793(92)80018-C |
| format | Article |
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Psychology</topic><topic>Fundamental immunology</topic><topic>Jelly coat egg</topic><topic>KDN</topic><topic>Lewis X antigen</topic><topic>Lewis Y antigen</topic><topic>Molecular immunology</topic><topic>Mucin</topic><topic>Pleurodeles waltlii</topic><topic>TAA</topic><topic>tumor-associated antigen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strecker, Gérard</creatorcontrib><creatorcontrib>Wieruszeski, Jean-Michel</creatorcontrib><creatorcontrib>Michalski, Jean-Claude</creatorcontrib><creatorcontrib>Alonso, Catherine</creatorcontrib><creatorcontrib>Boilly, Benoni</creatorcontrib><creatorcontrib>Montreuil, Jean</creatorcontrib><collection>Pascal-Francis</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strecker, Gérard</au><au>Wieruszeski, Jean-Michel</au><au>Michalski, Jean-Claude</au><au>Alonso, Catherine</au><au>Boilly, Benoni</au><au>Montreuil, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Lex, Ley and A Ley antigen determinants in KDN‐containing O‐linked glycan chains from Pleurodeles waltlii jelly coat eggs</atitle><jtitle>FEBS letters</jtitle><date>1992-02-17</date><risdate>1992</risdate><volume>298</volume><issue>1</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Novel acidic oligosaccharides were isolated in large amounts by reductive alkaline treatment of the jelly coat of Pleurodeles waltlii (Michah) eggs. 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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1992-02, Vol.298 (1), p.39-43 |
| issn | 0014-5793 1873-3468 |
| language | eng ; jpn |
| recordid | cdi_pascalfrancis_primary_5099167 |
| source | Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 2-keto-3-deoxy-d-glycero-d-galacto-nononic acid A Lewis Y antigen Antigenic determinants, haptens, artificial antigens Antigens Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Jelly coat egg KDN Lewis X antigen Lewis Y antigen Molecular immunology Mucin Pleurodeles waltlii TAA tumor-associated antigen |
| title | Characterization of Lex, Ley and A Ley antigen determinants in KDN‐containing O‐linked glycan chains from Pleurodeles waltlii jelly coat eggs |
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