Characterization of Lex, Ley and A Ley antigen determinants in KDN‐containing O‐linked glycan chains from Pleurodeles waltlii jelly coat eggs

Novel acidic oligosaccharides were isolated in large amounts by reductive alkaline treatment of the jelly coat of Pleurodeles waltlii (Michah) eggs. The oligosaccharides were found to contain the newly described KDN as acidic monosaccharide and possess either the Lex, Ley and A Ley antigenic determi...

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Veröffentlicht in:	FEBS letters 1992-02, Vol.298 (1), p.39-43
Hauptverfasser:	Strecker, Gérard, Wieruszeski, Jean-Michel, Michalski, Jean-Claude, Alonso, Catherine, Boilly, Benoni, Montreuil, Jean
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	2-keto-3-deoxy-d-glycero-d-galacto-nononic acid A Lewis Y antigen Antigenic determinants, haptens, artificial antigens Antigens Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Jelly coat egg KDN Lewis X antigen Lewis Y antigen Molecular immunology Mucin Pleurodeles waltlii TAA tumor-associated antigen
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Beschreibung
Zusammenfassung:	Novel acidic oligosaccharides were isolated in large amounts by reductive alkaline treatment of the jelly coat of Pleurodeles waltlii (Michah) eggs. The oligosaccharides were found to contain the newly described KDN as acidic monosaccharide and possess either the Lex, Ley and A Ley antigenic determinants. Occurrence of Lex and Ley determinants previously recognized as tumor‐associated antigen (TAA) demonstrates that mucins of lower animals may represent a rich and easily available source for preparing TAA. Moreover, it reinforces the hypothesis according to which TAA are evolution markers.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(92)80018-C