IgG Interference in Second Generation Enzymeimmunoassays for Anti-Hepatitis C Virus Antibodies

The interference of endogenous IgG in the identification of anti-HCV antibodies was studied in three second-generation enzymeimmunoassays. The addition of increasing concentrations of this immunoglobulin led to the appearance of false positives. The results obtained confirm the hypothesis that a non...

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Veröffentlicht in:	Journal of immunoassay (Monticello, N.Y.) N.Y.), 1993-09, Vol.14 (3), p.183-189
Hauptverfasser:	Borque, Luis, Maside, Carlos, Rus, Antonio, Elena, Angel, del Cura, Jorge, Gastañares, Maria J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences enzymeimmunoassay Evaluation Studies as Topic False Positive Reactions Hepacivirus - immunology Hepatitis Antibodies - blood Hepatitis C Antibodies hepatitis C virus antibodies Human viral diseases Humans IgG interference Immunoenzyme Techniques - statistics & numerical data Immunoglobulin G - blood Infectious diseases Medical sciences Sensitivity and Specificity Viral diseases Viral hepatitis
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Beschreibung
Zusammenfassung:	The interference of endogenous IgG in the identification of anti-HCV antibodies was studied in three second-generation enzymeimmunoassays. The addition of increasing concentrations of this immunoglobulin led to the appearance of false positives. The results obtained confirm the hypothesis that a non-specific binding of the IgG with the support material used was responsible for this interference.
ISSN:	0197-1522 2332-4090
DOI:	10.1080/15321819308019848