Reassignment of Human Renin Gene to Chromosome 1q32 in Studies of a (1;4)(q42;p16) Translocation

The human renin gene (REN) has been assigned to chromosome Iq42. Linkage studies are, however, inconsistent with this localization. We therefore reexamined the question of the location of REN using a patient whose distal chromosome lq arm was translocated to chromosome 4 [(1;4)(q42;pl6)]. In situ hybridization using a ³H-labelled REN probe demonstrated hybridization signals confined to the q32 band of chromosome 1, with radioactivity in the translocated 1q42 region being similar to the low levels along all other chromosomes.