PRODUCTION OF NEW ANTHRACYCLINE ANTIBIOTICS 1-HYDROXY-OXAUNOMYCIN AND 6-DEOXYOXAUNOMYCIN BY LIMITED BIO-SYNTHETIC CONVERSION USING A DAUNORUBICIN-NEGATIVE MUTANT

PRODUCTION OF NEW ANTHRACYCLINE ANTIBIOTICS 1-HYDROXY-OXAUNOMYCIN AND 6-DEOXYOXAUNOMYCIN BY LIMITED BIO-SYNTHETIC CONVERSION USING A DAUNORUBICIN-NEGATIVE MUTANT

A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolat...

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Veröffentlicht in:Journal of antibiotics 1992/10/25, Vol.45(10), pp.1609-1617
Hauptverfasser: YOSHIMOTO, AKIHIRO, JOHDO, OSAMU, TONE, HIROSHI, OKAMOTO, ROKUROU, NAGANAWA, HIROSHI, SAWA, TSUTOMU, TAKEUCHI, TOMIO
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Fundamental and applied biological sciences. Psychology
Microbiology
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Zusammenfassung:A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.1609