A Convenient Route to 2′-Allenyl Nucleosides

A Convenient Route to 2′-Allenyl Nucleosides

The first synthesis of allenic nucleosides derived from natural ribonucleosides is reported. 2′-Deoxy-2′-(ethenylidene)cytidine (8) and 2′-deoxy-2′-(ethenylidine)adenosine (21) were prepared by a modification of the method developed by Tsuji and co-workers for the synthesis of allenes. The biologica...

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Veröffentlicht in:Nucleosides & nucleotides 1994-03, Vol.13 (1-3), p.585-598
Hauptverfasser: Jarvi, Esa T., McCarthy, James R.
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Preparations and properties
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Zusammenfassung:The first synthesis of allenic nucleosides derived from natural ribonucleosides is reported. 2′-Deoxy-2′-(ethenylidene)cytidine (8) and 2′-deoxy-2′-(ethenylidine)adenosine (21) were prepared by a modification of the method developed by Tsuji and co-workers for the synthesis of allenes. The biological rationale for the synthesis of these compounds is discussed.
ISSN:0732-8311
2332-3892
DOI:10.1080/15257779408013264