Phosphinic Acid-Based C2-Symmetrical Inhibitors of HIV-Protease

As analogues of the transition state of peptide hydrolysis, phosphinic acid groups can be incorporated in a C2‐symmetrical peptide environment based on the geometry of the HIV‐protease. This leads to compounds such as 1, potent inhibitors of this key enzyme of the AIDS pathogens. R = 1‐naphthyl....

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Veröffentlicht in:	Angewandte Chemie (International ed.) 1993-12, Vol.32 (12), p.1720-1722
Hauptverfasser:	Peyman, Anusch, Buidt, Karl-Heinz, Spanig, Jörg, Ruppert, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	As analogues of the transition state of peptide hydrolysis, phosphinic acid groups can be incorporated in a C2‐symmetrical peptide environment based on the geometry of the HIV‐protease. This leads to compounds such as 1, potent inhibitors of this key enzyme of the AIDS pathogens. R = 1‐naphthyl.
ISSN:	0570-0833 1521-3773
DOI:	10.1002/anie.199317201