A practical approach to the synthesis of 14C-labeled amino acid and simple peptide

A convenient method for the synthesis of phenylmethyl N‐methyl (carboxy‐14C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino acid Z enabled u...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1994-02, Vol.34 (2), p.107-115
Hauptverfasser:	Ekhato, I. Victor, Huang, Che C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 cell line Chemistry Exact sciences and technology Intestinal peptide transporter N-glycyl-N-methyl (carboxy-14C) glycine Organic chemistry organostannane compound Peptides Preparations and properties transmetalation
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Beschreibung
Zusammenfassung:	A convenient method for the synthesis of phenylmethyl N‐methyl (carboxy‐14C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino acid Z enabled us to synthesize target N‐glycyl‐N‐methyl(carboxy‐14C) glycine (10) by conventional coupling protocol.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.2580340202