1α‐Hydroxyvitamin D3 inhibits Type II collagen‐induced arthritis in rats
The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelli...
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| Veröffentlicht in: | FEBS letters 1994-01, Vol.337 (3), p.248-250 |
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| creator | Tsuji, Michiko Fujii, Katsuyuki Nakano, Toshiaki Nishii, Yasuho |
| description | The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti‐Type II collagen antibodies was decreased in the 1α‐hydroxyvitamin D3 treated‐group. In contrast, 24,25‐dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1α‐hydroxyvitamin D3 on Type II collagen‐induced arthritis in rats and indicate that it has an antirheumatic effect. |
| doi_str_mv | 10.1016/0014-5793(94)80201-7 |
| format | Article |
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Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti‐Type II collagen antibodies was decreased in the 1α‐hydroxyvitamin D3 treated‐group. In contrast, 24,25‐dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1α‐hydroxyvitamin D3 on Type II collagen‐induced arthritis in rats and indicate that it has an antirheumatic effect.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(94)80201-7</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>1α,25-(OH)2-D3,1α,25-dihydroxyvitamin D3 ; 1α-Hydroxy vitamin D3 ; 1α-OH-D3, 1α-hydroxyvitamin D3 ; 24,25-(OH)2-D3, 24,25-dihydroxyvitamin D3 ; Anti-Type II collagen antibody ; Biological and medical sciences ; Cell physiology ; CIA, collagen-induced arthritis ; Collagen-induced arthritis ; ELISA, enzyme-linked immunosorbent assay ; Fundamental and applied biological sciences. Psychology ; Molecular and cellular biology ; RA, rheumatoid arthritis ; Responses to growth factors, tumor promotors, other factors ; Rheumatoid arthritis</subject><ispartof>FEBS letters, 1994-01, Vol.337 (3), p.248-250</ispartof><rights>FEBS Letters 337 (1994) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3896289$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuji, Michiko</creatorcontrib><creatorcontrib>Fujii, Katsuyuki</creatorcontrib><creatorcontrib>Nakano, Toshiaki</creatorcontrib><creatorcontrib>Nishii, Yasuho</creatorcontrib><title>1α‐Hydroxyvitamin D3 inhibits Type II collagen‐induced arthritis in rats</title><title>FEBS letters</title><description>The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti‐Type II collagen antibodies was decreased in the 1α‐hydroxyvitamin D3 treated‐group. In contrast, 24,25‐dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1α‐hydroxyvitamin D3 on Type II collagen‐induced arthritis in rats and indicate that it has an antirheumatic effect.</description><subject>1α,25-(OH)2-D3,1α,25-dihydroxyvitamin D3</subject><subject>1α-Hydroxy vitamin D3</subject><subject>1α-OH-D3, 1α-hydroxyvitamin D3</subject><subject>24,25-(OH)2-D3, 24,25-dihydroxyvitamin D3</subject><subject>Anti-Type II collagen antibody</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>CIA, collagen-induced arthritis</subject><subject>Collagen-induced arthritis</subject><subject>ELISA, enzyme-linked immunosorbent assay</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Molecular and cellular biology</topic><topic>RA, rheumatoid arthritis</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Rheumatoid arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuji, Michiko</creatorcontrib><creatorcontrib>Fujii, Katsuyuki</creatorcontrib><creatorcontrib>Nakano, Toshiaki</creatorcontrib><creatorcontrib>Nishii, Yasuho</creatorcontrib><collection>Pascal-Francis</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuji, Michiko</au><au>Fujii, Katsuyuki</au><au>Nakano, Toshiaki</au><au>Nishii, Yasuho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1α‐Hydroxyvitamin D3 inhibits Type II collagen‐induced arthritis in rats</atitle><jtitle>FEBS letters</jtitle><date>1994-01-17</date><risdate>1994</risdate><volume>337</volume><issue>3</issue><spage>248</spage><epage>250</epage><pages>248-250</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti‐Type II collagen antibodies was decreased in the 1α‐hydroxyvitamin D3 treated‐group. In contrast, 24,25‐dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1α‐hydroxyvitamin D3 on Type II collagen‐induced arthritis in rats and indicate that it has an antirheumatic effect.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><doi>10.1016/0014-5793(94)80201-7</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1994-01, Vol.337 (3), p.248-250 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 1α,25-(OH)2-D3,1α,25-dihydroxyvitamin D3 1α-Hydroxy vitamin D3 1α-OH-D3, 1α-hydroxyvitamin D3 24,25-(OH)2-D3, 24,25-dihydroxyvitamin D3 Anti-Type II collagen antibody Biological and medical sciences Cell physiology CIA, collagen-induced arthritis Collagen-induced arthritis ELISA, enzyme-linked immunosorbent assay Fundamental and applied biological sciences. Psychology Molecular and cellular biology RA, rheumatoid arthritis Responses to growth factors, tumor promotors, other factors Rheumatoid arthritis |
| title | 1α‐Hydroxyvitamin D3 inhibits Type II collagen‐induced arthritis in rats |
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