1α‐Hydroxyvitamin D3 inhibits Type II collagen‐induced arthritis in rats

The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelli...

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Veröffentlicht in:FEBS letters 1994-01, Vol.337 (3), p.248-250
Hauptverfasser: Tsuji, Michiko, Fujii, Katsuyuki, Nakano, Toshiaki, Nishii, Yasuho
Format: Artikel
Sprache:eng
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Zusammenfassung:The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti‐Type II collagen antibodies was decreased in the 1α‐hydroxyvitamin D3 treated‐group. In contrast, 24,25‐dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1α‐hydroxyvitamin D3 on Type II collagen‐induced arthritis in rats and indicate that it has an antirheumatic effect.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(94)80201-7