Isolation of Myosin Light Chain Kinase Inhibitors from Microorganisms: Dehydroaltenusin, Altenusin, Atrovenetinone, and Cyclooctasulfur

Dehydroaltenusin, cyciooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticil/us subsp. tsukushiensis ATCC-21633, Penicillium sp. SPC-16375, and Penicillium sp. SPC-16524, respectively, as new myosin light chain ki...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995, Vol.59 (7), p.1333-1335
Hauptverfasser: Nakanishi, Satoshi, Toki, Shinichiro, Saitoh, Yutaka, Tsukuda, Eiji, Kawahara, Kiyotaka, Ando, Katsuhiko, Matsuda, Yuzuru
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Sprache:eng
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Zusammenfassung:Dehydroaltenusin, cyciooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticil/us subsp. tsukushiensis ATCC-21633, Penicillium sp. SPC-16375, and Penicillium sp. SPC-16524, respectively, as new myosin light chain kinase (MLCK) inhibitors. These compounds inhibited the calmodulin-dependent activity of MLCK with IC 50 values of 0.69, 0.86, 3.7, and 340 μM, respectively. Among them, dehydroaltenusin was the best MLCK inhibitor in terms of potency and selectivity examined in the purified enzyme systems.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.59.1333