Antifungal anthraquinones from Morinda lucida

Antifungal anthraquinones from Morinda lucida

Abstract Bioactivity guided fractionation of a dichloromethane extract of Morinda lucida Benth. (Rubiaceae) roots has led to the isolation often anthraquinones. Four of these were active against Cladosporium cucumerinum and Candida albicans in bioautographic (TLC) assays. In-depth investigation of a...

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Veröffentlicht in:International journal of pharmacognosy 1995, Vol.33 (2), p.107-114
Hauptverfasser: Rath, Guido, Ndonzao, Menavanza, Hostettmann, Kurt
Format: Artikel
Sprache:eng
Schlagworte:
Anthraquinones
antifungal
Biological and medical sciences
C-NMR
General pharmacology
Medical sciences
Morinda lucida
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rubiaceae
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Zusammenfassung:Abstract Bioactivity guided fractionation of a dichloromethane extract of Morinda lucida Benth. (Rubiaceae) roots has led to the isolation often anthraquinones. Four of these were active against Cladosporium cucumerinum and Candida albicans in bioautographic (TLC) assays. In-depth investigation of activity against three human pathogenic fungi showed that alizarin-1-methyl ether displayed the highest activity.
ISSN:1388-0209
0925-1618
1744-5116
DOI:10.3109/13880209509055208