A modified linear estimation approach for solving biomagnetic inverse problems

A computer simulation study of the biomagnetic inverse problem was performed. A realistically shaped, multi-compartment boundary element model of the human body was used to localize dipolar current sources within the heart. The minimum-norm solution of the often used Linear Estimation Approach (LEA) was modified to improve localization accuracy. By multiplying the lead field matrix with two new weighting matrices and implementing a procedure for shifting the reconstructed current dipoles the authors could avoid the well-known blurring effect which can be observed if the common LEA is used. The new modified linear estimation approach (MLEA) was applied to localization of different dipole configurations. It can be used to reconstruct volume sources as well.