Topical Antiinflammatory Activity of Two Pimarane Diterpenes from Kaempferia pulchra

Topical Antiinflammatory Activity of Two Pimarane Diterpenes from Kaempferia pulchra

Two diterpenes, 2α‐acetoxysandraracopimaradien‐1α‐ol (1) and sandaracopimaradien‐1α,2α‐diol (2) isolated from Kaempferia pulchra Ridl. (Zingiberaceae), have been assayed for topical antiinflammatory activity in the model of 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced ear oedema in rats. Both substa...

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Veröffentlicht in:Phytotherapy research 1996-02, Vol.10 (6), p.534-535
Hauptverfasser: Sematong, Tuanta, Reutrakul, Vichai, Tuchinda, Patoomratana, Claeson, Per, Pongprayoon, Ubonwan, Nahar, Nilufar
Format: Artikel
Sprache:eng
Schlagworte:
antiinflammatory activity
Biological and medical sciences
diterpenes
General pharmacology
Kaempferia pulchra
maxi-K channels
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sandaracopimaradien
Zingiberaceae
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Zusammenfassung:Two diterpenes, 2α‐acetoxysandraracopimaradien‐1α‐ol (1) and sandaracopimaradien‐1α,2α‐diol (2) isolated from Kaempferia pulchra Ridl. (Zingiberaceae), have been assayed for topical antiinflammatory activity in the model of 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced ear oedema in rats. Both substances were found active and the ID50‐values were estimated to 330 and 50 μg/ear, respectively. The ID50‐value of the reference drug diclofenac was calculated to 90 μg/ear
ISSN:0951-418X
1099-1573
DOI:10.1002/(SICI)1099-1573(199609)10:6<534::AID-PTR890>3.0.CO;2-C