Synthesis of the Interferon-α Inducer Imiquimod by Thermal Electrocyclic Reactions of 1- and 2-Azahexatriene Systems

The interferon-α inducer imiquimod (1), possessing an imidazo[4, 5-c]quinoline ring, has been newly synthesized by two routes based on thermal electrocyclic reactions of 1- and 2-azahexatriene systems inovlving the imidazole 4, 5-bond.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1996/04/15, Vol.44(4), pp.709-714
Hauptverfasser:	YOSHIOKA, Haruyuki, MATSUYA, Yuhji, CHOSHI, Tominari, SUGINO, Eiichi, HIBINO, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	azahexatriene system Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings imidazo[4, 5-c]quinoline imiquimod Organic chemistry Preparations and properties synthesis thermal electocyclic reaction
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Beschreibung
Zusammenfassung:	The interferon-α inducer imiquimod (1), possessing an imidazo[4, 5-c]quinoline ring, has been newly synthesized by two routes based on thermal electrocyclic reactions of 1- and 2-azahexatriene systems inovlving the imidazole 4, 5-bond.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.44.709