The predicted amino acid sequence of the Salmonella typhimurium virulence gene mviA+ strongly indicates that MviA is a regulator protein of a previously unknown S. typhimurium response regulator family

The Salmonella typhimurium virulence gene mviA+ has a predicted amino acid sequence with homology to the N-terminal 112-amino-acid sequence of response regulator proteins. A previously described mutant allele (mviA), which restores virulence to avirulent LT2 strains, was shown to contain a point mut...

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Veröffentlicht in:Infection and immunity 1996-06, Vol.64 (6), p.2365-2367
Hauptverfasser: Benjamin, W.H. Jr. (The University of Alabama at Birmingham, Birmingham, AL.), Wu, X.P, Swords, W.E
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Sprache:eng
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Zusammenfassung:The Salmonella typhimurium virulence gene mviA+ has a predicted amino acid sequence with homology to the N-terminal 112-amino-acid sequence of response regulator proteins. A previously described mutant allele (mviA), which restores virulence to avirulent LT2 strains, was shown to contain a point mutation which would be predicted to cause a single amino acid change, V-102 leads to G (W. H. Benjamin, Jr., J. Yother, P. Hall, and D. E. Briles, J. Exp. Med. 174:1073-1083, 1991). A comparison of the nucleotide sequence of mviA+ with that of the Escherichia coli and Salmonella typhi genes revealed a high degree of conservation
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.64.6.2365-2367.1996