Mn2+ and Mg2+ synergistically enhanced lactic acid production by Lactobacillus rhamnosus FTDC 8313 via affecting different stages of the hexose monophosphate pathway

AIMS: The study aimed to evaluate the effects of Mn²⁺and Mg²⁺on lactic acid production using response surface methodology and to further study their effects on interactions between the enzymes and substrates along the hexose monophosphate pathway using a molecular modelling approach. METHODS AND RES...

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Veröffentlicht in:	Journal of applied microbiology 2014-03, Vol.116 (3), p.644-653
Hauptverfasser:	Lew, L.‐C, Choi, S.‐B, Tan, P.‐L, Liong, M.‐T
Format:	Artikel
Sprache:	eng
Schlagworte:	binding capacity binding sites Biological and medical sciences biotechnology enzyme substrates Fundamental and applied biological sciences. Psychology glucose-6-phosphate 1-dehydrogenase glyceraldehyde-3-phosphate dehydrogenase lactic acid Lactobacillus Lactobacillus rhamnosus magnesium magnesium sulfate manganese manganese sulfate metal ions Microbiology modelling phosphogluconate dehydrogenase phosphopyruvate hydratase probiotics pyruvate kinase regression analysis response surface methodology
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Zusammenfassung:	AIMS: The study aimed to evaluate the effects of Mn²⁺and Mg²⁺on lactic acid production using response surface methodology and to further study their effects on interactions between the enzymes and substrates along the hexose monophosphate pathway using a molecular modelling approach. METHODS AND RESULTS: A rotatable central composite design matrix for lactic acid production was generated with two independent factors namely, manganese sulfate and magnesium sulfate. The second‐order regression model indicated that the quadratic model was significant (P
ISSN:	1364-5072 1365-2672
DOI:	10.1111/jam.12399