1β-Methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 1. Synthesis and Antibacterial Activity of BO-2502A and Its Related Compounds

The synthesis and biological activity of (lR, 5S, 6S)-2-[(3S, 5S)-5-substituted pyrrolidin-3-ylthio]6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid, in which lactams and cyclic amines are introduced as substituents, are described. They showed potent antibacterial activity against G...

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Veröffentlicht in:	Journal of antibiotics 1997/07/25, Vol.50(7), pp.567-585
Hauptverfasser:	OHTAKE, NORIKAZU, YAMADA, KOJI, MANO, EIICHI, OKAMOTO, OSAMU, USHIJIMA, RYOSUKE, NAKAGAWA, SUSUMU
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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Zusammenfassung:	The synthesis and biological activity of (lR, 5S, 6S)-2-[(3S, 5S)-5-substituted pyrrolidin-3-ylthio]6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid, in which lactams and cyclic amines are introduced as substituents, are described. They showed potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa. Among them, BO-2502A (4h-1) was selected for further evaluation.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.50.567