Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum

Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum

We examined the effects of oral L-hydroxyproline (Hyp) on collagen in the body. After 2 weeks' administration of Hyp (0.5 or 1 g/kg) to F344 male rats, the soluble collagen content of the skin had increased, and the serum concentration of collagen peptides was correlated with the skin content o...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (6), p.1242-1244
Hauptverfasser: AOKI, Mami, SUTO, Kouzou, KOMATSU, Miho, KAMIMURA, Ayako, MORISHITA, Koji, YAMASAKI, Motoo, TAKAO, Toshifumi
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Animals
Biological and medical sciences
collagen
Collagen - metabolism
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Hydroxyproline - metabolism
Hydroxyproline - pharmacology
L-hydroxyproline
Male
oral intake
Peptide Fragments - blood
Rats
Rats, Inbred F344
Skin - drug effects
Skin - metabolism
Solubility
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Zusammenfassung:We examined the effects of oral L-hydroxyproline (Hyp) on collagen in the body. After 2 weeks' administration of Hyp (0.5 or 1 g/kg) to F344 male rats, the soluble collagen content of the skin had increased, and the serum concentration of collagen peptides was correlated with the skin content of soluble collagen. This result suggests that oral Hyp augmented collagen metabolism.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.120058