Abscess formation in Listeria monocytogenes-infected γδT cell deficient mouse mutants involves αβT cells

Although mutant mice lacking γδT cells resolve Listeria monocytogenesinfection, extensive abscesses are formed. Manifestation of these inflammatory lesions is prevented by in vivodepletion with monoclonal antibodies of CD4, CD8 or both T cell subsets. We conclude that these inflammatory tissue react...

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Veröffentlicht in:Microbial pathogenesis 1997, Vol.22 (2), p.123-128
Hauptverfasser: Thoma-Uszynski, Sybille, Ladel, Christoph H., Kaufmann, Stefan H.E.
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container_title Microbial pathogenesis
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creator Thoma-Uszynski, Sybille
Ladel, Christoph H.
Kaufmann, Stefan H.E.
description Although mutant mice lacking γδT cells resolve Listeria monocytogenesinfection, extensive abscesses are formed. Manifestation of these inflammatory lesions is prevented by in vivodepletion with monoclonal antibodies of CD4, CD8 or both T cell subsets. We conclude that these inflammatory tissue reactions develop when αβ T cells of either CD4 or CD8 phenotype are released from control by γδT cells.
doi_str_mv 10.1006/mpat.1996.0095
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ispartof Microbial pathogenesis, 1997, Vol.22 (2), p.123-128
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source Elsevier ScienceDirect Journals Complete
subjects abscess formation
Bacterial diseases
Bacteriology
Biological and medical sciences
Experimental bacterial diseases and models
Fundamental and applied biological sciences. Psychology
Infectious diseases
listeriosis
Medical sciences
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
αβ T cells
γδT cells
title Abscess formation in Listeria monocytogenes-infected γδT cell deficient mouse mutants involves αβT cells
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