Abscess formation in Listeria monocytogenes-infected γδT cell deficient mouse mutants involves αβT cells

Although mutant mice lacking γδT cells resolve Listeria monocytogenesinfection, extensive abscesses are formed. Manifestation of these inflammatory lesions is prevented by in vivodepletion with monoclonal antibodies of CD4, CD8 or both T cell subsets. We conclude that these inflammatory tissue reactions develop when αβ T cells of either CD4 or CD8 phenotype are released from control by γδT cells.