Mean Platelet Volume and Integrin Alleles Correlate With Levels of Integrins αIIbβ3 and α2β1 in Acute Coronary Syndrome Patients and Normal Subjects

OBJECTIVE—The interindividual variation in platelet α2β1 exceeds a 2-fold variance in platelet αIIbβ3 level. Our objective was to parse the contribution of mean platelet volume (MPV) and integrin gene alleles to this variation in large cohorts of patients with acute coronary syndrome (ACS) and normal subjects. METHODS AND RESULTS—Platelet αIIbβ3 and α2β1 levels were measured by flow cytometry in whole blood from 320 ACS patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs28095, and ITGB3 rs5918 alleles. In all subjects, a strong direct correlation was found between MPV and αIIbβ3 level (P