Effects of a Plum (Prunus mume Siebold and Zucc.) Ethanol Extract on the Immune System in Vivo and in Vitro

The effect of a plum ethanol extract (PEE) on immunity was analyzed. An oral administration of PEE increased the interleukin (IL)-12p40 concentration in the serum and T-cell ratio in the spleen. In vitro studies revealed that PEE stimulated IL-12p70 production in peritoneal macrophages and natural k...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (10), p.2011-2013
Hauptverfasser:	TSUJI, Ryohei, KOIZUMI, Hideki, FUJIWARA, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Ethanol - chemistry Female Fundamental and applied biological sciences. Psychology immune enhancement Immunity, Innate - drug effects innate immunity interleukin-12 Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Mice Plant Extracts - pharmacology plum ethanol extract Prunus Prunus - chemistry Prunus mume ripeness
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Zusammenfassung:	The effect of a plum ethanol extract (PEE) on immunity was analyzed. An oral administration of PEE increased the interleukin (IL)-12p40 concentration in the serum and T-cell ratio in the spleen. In vitro studies revealed that PEE stimulated IL-12p70 production in peritoneal macrophages and natural killer activity. These findings suggest that PEE enhanced the immune function by stimulating innate immune cells.
ISSN:	0916-8451 1347-6947 1347-6947
DOI:	10.1271/bbb.100886