Large-Scale Ambulatory Study of Postprandial Jejunal Motility in Irritable Bowel Syndrome
Background: The relationship of small-bowel dysmotility to dietary intake in irritable bowel syndrome (IBS) is obscure. Methods: This study evaluated postprandial jejunal motility in IBS patients classified as constipation-predominant (n=25) or diarrhoea-predominant (n=35) and compared results again...
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Veröffentlicht in: | Scandinavian journal of gastroenterology 1997, Vol.32 (1), p.39-47 |
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Zusammenfassung: | Background: The relationship of small-bowel dysmotility to dietary intake in irritable bowel syndrome (IBS) is obscure. Methods: This study evaluated postprandial jejunal motility in IBS patients classified as constipation-predominant (n=25) or diarrhoea-predominant (n=35) and compared results against 18 volunteers. Twenty-four-hour ambulatory jejunal manometry was carried out in all subjects, and recordings were analysed by microcomputer and visual assessment. Results: By means of analysis of variance (fitting factors for channels, meals, and time periods) postprandial contraction frequency was greater in both patient groups compared with normal (constipation-predominant versus normal, diarrhoea-predominant versus normal; P < 0.001). In the constipation-predominant cohort, contraction amplitudes were lower (constipation-predominant versus normal; P < 0.002). Discrete cluster contractions occurred with similar frequency and duration in both patient and volunteer groups. Conclusions: Quantitative differences of postprandial jejunal contraction characteristics have been shown between patients with IBS and healthy volunteers. Contraction frequency is greater than normal in both diarrhoea-and constipation-predominant categories, whereas contraction amplitudes are lower in constipation-predominant patients. |
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ISSN: | 0036-5521 1502-7708 |
DOI: | 10.3109/00365529709025061 |