Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (7), p.1386-1388
Hauptverfasser:	XU, Jing, GUO, Ping, LIU, Cuizhou, SUN, Zhanping, GUI, Liping, GUO, Yuanqiang, YAMAKUNI, Tohru, OHIZUMI, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects dietrpenoids Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - isolation & purification Fritillaria Fritillaria - chemistry Fritillaria ebeiensis Fundamental and applied biological sciences. Psychology Humans kaurane Magnetic Resonance Spectroscopy Molecular Conformation Molecular Structure Neuroblastoma Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification neuroprotective effect Plant Roots - chemistry Spectrum Analysis
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Zusammenfassung:	The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP + -induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
ISSN:	0916-8451 1347-6947 1347-6947
DOI:	10.1271/bbb.110146