The Crystal Structure of SDR-Type Pyridoxal 4-Dehydrogenase of Mesorhizobium loti

Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B 6 compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB c...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (2), p.388-390
Hauptverfasser:	CHU, Huy Nhat, KOBAYASHI, Jun, MIKAMI, Bunzo, YAGI, Toshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	4-pyridoxolactone Alcohol Oxidoreductases - chemistry Alcohol Oxidoreductases - metabolism Biochemistry Biological and medical sciences Biotechnology Crystal structure Crystallography, X-Ray Degradation Enzymes Fundamental and applied biological sciences. Psychology Mesorhizobium loti Models, Molecular Molecular structure Oxidoreductases - chemistry Oxidoreductases - metabolism Pathways Protein Conformation Proteobacteria - enzymology Pyridoxine pyridoxine-degradation short-chain dehydrogenase/reductase symbiotic bacterium vitamin B Vitamins
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Zusammenfassung:	Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B 6 compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD + -bound enzyme.
ISSN:	0916-8451 1347-6947 1347-6947
DOI:	10.1271/bbb.100748