Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase

Tetrahydrobiopterine (6BH 4 ) can diminish the oxidative stress undergone by keratinocytes and melanocytes by reducing the o-quinones generated by the oxidation of the corresponding o-diphenols. We found that 6BH 4 and their analogs reduced all the o-quinones studied. The formal potentials of differ...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (5), p.1108-1109
Hauptverfasser:	Garcia-Molina, F., University of Murcia (Spain), Munoz-Munoz, J.L, Martinez-Ortiz, F, Tudela, J, Garcia-Canovas, F, Rodriguez-Lopez, J.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinones - metabolism Biocatalysis Biological and medical sciences Biopterins - chemistry Biopterins - pharmacology COMPOSE ORGANIQUE COMPOSE PHENOLIQUE COMPUESTOS FENOLICOS COMPUESTOS ORGANICOS EPIDERME EPIDERMIS Fundamental and applied biological sciences. Psychology http://www.fao.org/aos/agrovoc#c_2617 http://www.fao.org/aos/agrovoc#c_36207 http://www.fao.org/aos/agrovoc#c_4088 http://www.fao.org/aos/agrovoc#c_5384 http://www.fao.org/aos/agrovoc#c_5472 http://www.fao.org/aos/agrovoc#c_5474 http://www.fao.org/aos/agrovoc#c_5772 http://www.fao.org/aos/agrovoc#c_6385 http://www.fao.org/aos/agrovoc#c_6412 http://www.fao.org/aos/agrovoc#c_6483 KERATIN KERATINE MELANINAS MELANINE MELANINS Monophenol Monooxygenase - metabolism o-diphenols ORGANIC COMPOUNDS OXIDACION OXIDATION Oxidation-Reduction OXIDOREDUCTASES OXIDORREDUCTASAS OXYDATION OXYDOREDUCTASE PHENOLIC COMPOUNDS PIRIDINAS Pterins - chemistry Pterins - pharmacology PYRIDINE PYRIDINES QUERATINAS QUINONAS QUINONE QUINONES REDUCCION REDUCTION tetrahydropterines tyrosinase voltammograms
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Zusammenfassung:	Tetrahydrobiopterine (6BH 4 ) can diminish the oxidative stress undergone by keratinocytes and melanocytes by reducing the o-quinones generated by the oxidation of the corresponding o-diphenols. We found that 6BH 4 and their analogs reduced all the o-quinones studied. The formal potentials of different quinone/diphenol pairs indicate that the o-quinones with withdrawing groups are more potent oxidants than those with donating groups.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.90924