The pathway of leucine to mevalonate in halophilic archaea: Efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum

The pathway of leucine to mevalonate, which has attracted attention in the study of the biosynthesis of isoprenoid in parasitic protozoa and myxobacterium, was observed in the biosynthesis of the lipid core in halophilic archaea. The involvement of isovaleryl-CoA dehydrogenase was strongly suggested...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (2), p.443-446
1. Verfasser: Yamauchi, N., Kyushu Univ., Fukuoka (Japan)
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description The pathway of leucine to mevalonate, which has attracted attention in the study of the biosynthesis of isoprenoid in parasitic protozoa and myxobacterium, was observed in the biosynthesis of the lipid core in halophilic archaea. The involvement of isovaleryl-CoA dehydrogenase was strongly suggested, with stereospecific conversion of the diastereotopic methyl group of leucine to isoprenoidal lipid.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry
subjects Archaea
Biochemistry
Biological and medical sciences
BIOSINTESIS
BIOSYNTHESE
BIOSYNTHESIS
Biotechnology
diastereotopic methyl group
Fundamental and applied biological sciences. Psychology
Halobacteriales - genetics
Halobacteriales - metabolism
Halobacterium salinarum
Halobacterium salinarum - genetics
Halobacterium salinarum - metabolism
halophilic archaea
http://www.fao.org/aos/agrovoc#c_36399
http://www.fao.org/aos/agrovoc#c_4292
http://www.fao.org/aos/agrovoc#c_4807
http://www.fao.org/aos/agrovoc#c_928
ISOPRENOIDE
ISOPRENOIDES
ISOPRENOIDS
isovaleryl-CoA dehydrogenase
Isovaleryl-CoA Dehydrogenase - genetics
Isovaleryl-CoA Dehydrogenase - metabolism
LEUCINA
LEUCINE
Leucine - genetics
Leucine - metabolism
Lipids
Lipids - genetics
mevalonate pathway
Mevalonic Acid - metabolism
MICRO-ORGANISME
MICROORGANISMOS
MICROORGANISMS
Pathways
Protozoa
title The pathway of leucine to mevalonate in halophilic archaea: Efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum
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