The pathway of leucine to mevalonate in halophilic archaea: Efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum

The pathway of leucine to mevalonate, which has attracted attention in the study of the biosynthesis of isoprenoid in parasitic protozoa and myxobacterium, was observed in the biosynthesis of the lipid core in halophilic archaea. The involvement of isovaleryl-CoA dehydrogenase was strongly suggested...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (2), p.443-446
1. Verfasser:	Yamauchi, N., Kyushu Univ., Fukuoka (Japan)
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaea Biochemistry Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS Biotechnology diastereotopic methyl group Fundamental and applied biological sciences. Psychology Halobacteriales - genetics Halobacteriales - metabolism Halobacterium salinarum Halobacterium salinarum - genetics Halobacterium salinarum - metabolism halophilic archaea http://www.fao.org/aos/agrovoc#c_36399 http://www.fao.org/aos/agrovoc#c_4292 http://www.fao.org/aos/agrovoc#c_4807 http://www.fao.org/aos/agrovoc#c_928 ISOPRENOIDE ISOPRENOIDES ISOPRENOIDS isovaleryl-CoA dehydrogenase Isovaleryl-CoA Dehydrogenase - genetics Isovaleryl-CoA Dehydrogenase - metabolism LEUCINA LEUCINE Leucine - genetics Leucine - metabolism Lipids Lipids - genetics mevalonate pathway Mevalonic Acid - metabolism MICRO-ORGANISME MICROORGANISMOS MICROORGANISMS Pathways Protozoa
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Beschreibung
Zusammenfassung:	The pathway of leucine to mevalonate, which has attracted attention in the study of the biosynthesis of isoprenoid in parasitic protozoa and myxobacterium, was observed in the biosynthesis of the lipid core in halophilic archaea. The involvement of isovaleryl-CoA dehydrogenase was strongly suggested, with stereospecific conversion of the diastereotopic methyl group of leucine to isoprenoidal lipid.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.90814