Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa

A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1‐methyl‐2‐[(4Z,7Z)‐4,7‐tridecadienyl]‐4(1H)‐quinolone (2) and 1‐methyl‐2‐[(6Z,9Z)‐6,9‐pentadecadienyl]‐4(1H)‐quinolone (3) as blockers of angiote...

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Veröffentlicht in:	Phytotherapy research 1998-05, Vol.12 (3), p.212-214
Hauptverfasser:	Lee, Hyun Sun, Oh, Won Keun, Choi, Hee Cheol, Lee, Jun Won, Kang, Dae Ook, Park, Chan Sun, Mheen, Tae-Ick, Ahn, Jong Seog
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II receptor binding Biological and medical sciences Evodia rutaecarpa General pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments quinolone alkaloid Rutaceae
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Zusammenfassung:	A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1‐methyl‐2‐[(4Z,7Z)‐4,7‐tridecadienyl]‐4(1H)‐quinolone (2) and 1‐methyl‐2‐[(6Z,9Z)‐6,9‐pentadecadienyl]‐4(1H)‐quinolone (3) as blockers of angiotensin II receptor binding with IC50 values of 43.4 μM, 34.1 μM and 48.2 μM, respectively. © 1998 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/(SICI)1099-1573(199805)12:3<212::AID-PTR216>3.0.CO;2-5