Solubility of Flurbiprofen in CO2 and CO2 + Methanol

Solubility of Flurbiprofen in CO2 and CO2 + Methanol

The solubility of (R,S)-2-(2-fluorobiphenyl-4-yl)propanoic acid (flurbiprofen) in supercritical carbon dioxide and in a mixed solvent consisting of carbon dioxide and methanol at (303.15 and 313.15) K between the pressures of (10.0 and 20.0) MPa is reported. The solubilities were measured using a di...

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Veröffentlicht in:Journal of chemical and engineering data 2010-04, Vol.55 (4), p.1542-1546
Hauptverfasser: Chin, Gui Jin, Chee, Zi Hui, Chen, Wenda, Rajendran, Arvind
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
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Zusammenfassung:The solubility of (R,S)-2-(2-fluorobiphenyl-4-yl)propanoic acid (flurbiprofen) in supercritical carbon dioxide and in a mixed solvent consisting of carbon dioxide and methanol at (303.15 and 313.15) K between the pressures of (10.0 and 20.0) MPa is reported. The solubilities were measured using a direct visualization technique. The experimental data is described using the Peng−Robinson equation of state (PR EoS) together with a one-parameter van der Waals mixing rule.
ISSN:0021-9568
1520-5134
DOI:10.1021/je900674t