Machilin G and four neolignans from young fruits of Magnolia denudata show various degrees of inhibitory activity on nitric oxide (NO) production

Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1. Some but not all of the inhibiti...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-10, Vol.72 (10), p.2775-2778
Hauptverfasser:	Noshita, T.(Aomori Univ. (Japan)), Funayama, S, Hirakawa, T, Kidachi, Y, Ryoyama, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line COMPOSE HETEROCYCLIQUE COMPUESTOS HETEROCICLICOS denudatin EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE FRUIT Fruit - chemistry Fruit - growth & development FRUTO Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects HETEROCYCLIC COMPOUNDS INHIBICION INHIBITION Lignans - chemistry Lignans - classification Lignans - isolation & purification Lignans - pharmacology machilin G macrophage MAGNOLIA Magnolia - chemistry Magnolia - growth & development Magnolia denudata Mice Molecular Structure NITRIC OXIDE Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis nitric oxide synthase Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism OXIDO NITRICO OXYDE NITRIQUE PLANT EXTRACTS RODENTIA
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Zusammenfassung:	Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.80327