Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxi...

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Veröffentlicht in:	Journal of Clinical Microbiology 2008-04, Vol.46 (4), p.1530-1533
Hauptverfasser:	Åkerlund, Thomas, Persson, Ingela, Unemo, Magnus, Norén, Torbjörn, Svenungsson, Bo, Wullt, Marlene, Burman, Lars G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Anti-Bacterial Agents - pharmacology Aza Compounds - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins/genetics/metabolism Bacteriology Basic Medicine Biological and medical sciences Clostridium difficile Clostridium difficile - classification Clostridium difficile - drug effects Clostridium difficile - genetics Clostridium difficile - physiology Clostridium difficile/classification/drug effects/genetics/physiology Disease Outbreaks Enterocolitis, Pseudomembranous - epidemiology Enterocolitis, Pseudomembranous - microbiology Fluoroquinolones Fundamental and applied biological sciences. Psychology Humans Medical and Health Sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicinska och farmaceutiska grundvetenskaper Microbial Sensitivity Tests Microbiology Microbiology in the medical area Microbiology, immunology, infectious diseases Middle Aged Mikrobiologi inom det medicinska området Mikrobiologi, immunologi, infektionssjukdomar Miscellaneous Quinolines - pharmacology Repressor Proteins - genetics Repressor Proteins - metabolism Repressor Proteins/genetics/metabolism Ribotyping Spores, Bacterial - physiology Virulence
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Zusammenfassung:	Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.
ISSN:	0095-1137 1098-660X 1098-660X 1098-5530
DOI:	10.1128/JCM.01964-07