Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer
Fifty-eight men at high risk of prostate cancer or with low-grade prostate cancer were randomly assigned to consume 1 of 3 protein isolates containing 40 g protein: 1) soy protein (SPI+, 107 mg isoflavones/d); 2) alcohol-washed soy protein (SPI-,
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| Veröffentlicht in: | Nutrition and cancer 2008-01, Vol.60 (1), p.7-13 |
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| creator | Hamilton-Reeves, J.M Rebello, S.A Thomas, W Kurzer, M.S Slaton, J.W |
| description | Fifty-eight men at high risk of prostate cancer or with low-grade prostate cancer were randomly assigned to consume 1 of 3 protein isolates containing 40 g protein: 1) soy protein (SPI+, 107 mg isoflavones/d); 2) alcohol-washed soy protein (SPI-, |
| doi_str_mv | 10.1080/01635580701586770 |
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Proliferating cell nuclear antigen (PCNA), epidermal growth factor receptor, B-cell non-Hodgkin lymphoma-2 (Bcl-2), and Bcl-2-associated X protein (Bax) were assessed in baseline and ending prostate biopsy cores. Serum collected at 0, 3, and 6 mo was analyzed for total and free prostate specific antigen (PSA). Consumption of SPI+ did not alter any of the prostate cancer tumor markers. Bax expression decreased from baseline in the SPI- group, resulting in lower Bax expression than the MPI group. PCNA expression also decreased from baseline in the SPI- group, but this was not different from the other 2 groups. PSA did not differ among the groups at 3 or 6 mo. Interestingly, a lower rate of prostate cancer developed in the soy groups compared to the milk group (P = 0.01). These data suggest that 6-mo SPI+ consumption does not alter prostate tissue biomarkers, SPI- consumption exerts mixed effects, and less prostate cancer is detected after 6 mo of soy consumption regardless of isoflavone content.</description><identifier>ISSN: 0163-5581</identifier><identifier>EISSN: 1532-7914</identifier><identifier>DOI: 10.1080/01635580701586770</identifier><identifier>PMID: 18444130</identifier><identifier>CODEN: NUCADQ</identifier><language>eng</language><publisher>Philadelphia, PA: Taylor & Francis Group</publisher><subject>adults ; Aged ; animal proteins ; Animals ; B-cell non-Hodgkin lymphoma-2 X protein ; B-cell non-Hodgkin lymphoma-2-associated X protein ; bcl-2-Associated X Protein - metabolism ; Biological and medical sciences ; biomarkers ; Biomarkers - analysis ; Biomarkers - blood ; blood chemistry ; Dietary Proteins - administration & dosage ; disease prevention ; disease severity ; epidermal growth factor ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gynecology. Andrology. Obstetrics ; Humans ; isoflavones ; Isoflavones - administration & dosage ; Male ; Male genital diseases ; Medical sciences ; men ; milk proteins ; Milk Proteins - administration & dosage ; Neoplasm Staging ; Nephrology. Urinary tract diseases ; proliferating cell nuclear antigen ; Proliferating Cell Nuclear Antigen - metabolism ; prostate specific antigen ; Prostate-Specific Antigen - metabolism ; prostatic neoplasms ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - prevention & control ; protein isolates ; protein synthesis ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Receptor, Epidermal Growth Factor - metabolism ; receptors ; risk assessment ; soy protein ; Soybean Proteins - administration & dosage ; Time Factors ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition and cancer, 2008-01, Vol.60 (1), p.7-13</ispartof><rights>Copyright Taylor & Francis Group, LLC 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-a0b8105668b7bfe4afd26b5315e8e0f702ad9ce76bdb35a4df47cecf7bfe94e43</citedby><cites>FETCH-LOGICAL-c369t-a0b8105668b7bfe4afd26b5315e8e0f702ad9ce76bdb35a4df47cecf7bfe94e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/01635580701586770$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/01635580701586770$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20032727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18444130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamilton-Reeves, J.M</creatorcontrib><creatorcontrib>Rebello, S.A</creatorcontrib><creatorcontrib>Thomas, W</creatorcontrib><creatorcontrib>Kurzer, M.S</creatorcontrib><creatorcontrib>Slaton, J.W</creatorcontrib><title>Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer</title><title>Nutrition and cancer</title><addtitle>Nutr Cancer</addtitle><description>Fifty-eight men at high risk of prostate cancer or with low-grade prostate cancer were randomly assigned to consume 1 of 3 protein isolates containing 40 g protein: 1) soy protein (SPI+, 107 mg isoflavones/d); 2) alcohol-washed soy protein (SPI-, <6 mg isoflavones/d); or 3) milk protein (MPI). Proliferating cell nuclear antigen (PCNA), epidermal growth factor receptor, B-cell non-Hodgkin lymphoma-2 (Bcl-2), and Bcl-2-associated X protein (Bax) were assessed in baseline and ending prostate biopsy cores. Serum collected at 0, 3, and 6 mo was analyzed for total and free prostate specific antigen (PSA). Consumption of SPI+ did not alter any of the prostate cancer tumor markers. Bax expression decreased from baseline in the SPI- group, resulting in lower Bax expression than the MPI group. PCNA expression also decreased from baseline in the SPI- group, but this was not different from the other 2 groups. PSA did not differ among the groups at 3 or 6 mo. Interestingly, a lower rate of prostate cancer developed in the soy groups compared to the milk group (P = 0.01). These data suggest that 6-mo SPI+ consumption does not alter prostate tissue biomarkers, SPI- consumption exerts mixed effects, and less prostate cancer is detected after 6 mo of soy consumption regardless of isoflavone content.</description><subject>adults</subject><subject>Aged</subject><subject>animal proteins</subject><subject>Animals</subject><subject>B-cell non-Hodgkin lymphoma-2 X protein</subject><subject>B-cell non-Hodgkin lymphoma-2-associated X protein</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>blood chemistry</subject><subject>Dietary Proteins - administration & dosage</subject><subject>disease prevention</subject><subject>disease severity</subject><subject>epidermal growth factor</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>isoflavones</subject><subject>Isoflavones - administration & dosage</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>men</subject><subject>milk proteins</subject><subject>Milk Proteins - administration & dosage</subject><subject>Neoplasm Staging</subject><subject>Nephrology. Urinary tract diseases</subject><subject>proliferating cell nuclear antigen</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>prostate specific antigen</subject><subject>Prostate-Specific Antigen - metabolism</subject><subject>prostatic neoplasms</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - prevention & control</subject><subject>protein isolates</subject><subject>protein synthesis</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>receptors</subject><subject>risk assessment</subject><subject>soy protein</subject><subject>Soybean Proteins - administration & dosage</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-5581</issn><issn>1532-7914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklFrFDEUhYModlv9Ab5oXvSpU28mmUkGfFlKbQulFmqfQyZzU0dnJtsky7pP_etmu1sFCwqBQO537r3nEELeMDhioOAjsJpXlQIJrFK1lPCMzFjFy0I2TDwns029yADbI_sxfgcAybh6SfaYEkIwDjNyf-Ic2hSpdzT6NV0En7CfaB_9YBJS66e4HBep9xPNJ5djeng3k8VA296PJvzAEGkWjTjRVZ--0bPTq_PLQzq_nl8dUjN1dPCr4jaYDv_u8Iq8cGaI-Hp3H5Cbzydfj8-Kiy-n58fzi8LyukmFgVYxqOpatbJ1KIzryrqtOKtQITgJpekai7Juu5ZXRnROSIvWbeBGoOAH5MO2b55_t8SY9NhHi8NgJvTLqOuGVTlTlUG2BW1eNAZ0ehH67HGtGehN6vpJ6lnzdtd82Y7Y_VHsYs7A-x1gojWDC9l7H39zJQAvZSkzJ7dcPzkfRrPyYeh0MuvBh0fRk_E6_UxZ-em_Sv4vB--2cme8Nrch0zfXJeTdQW0-k-K_ACp4udw</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Hamilton-Reeves, J.M</creator><creator>Rebello, S.A</creator><creator>Thomas, W</creator><creator>Kurzer, M.S</creator><creator>Slaton, J.W</creator><general>Taylor & Francis Group</general><general>Taylor& Francis</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer</title><author>Hamilton-Reeves, J.M ; Rebello, S.A ; Thomas, W ; Kurzer, M.S ; Slaton, J.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-a0b8105668b7bfe4afd26b5315e8e0f702ad9ce76bdb35a4df47cecf7bfe94e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adults</topic><topic>Aged</topic><topic>animal proteins</topic><topic>Animals</topic><topic>B-cell non-Hodgkin lymphoma-2 X protein</topic><topic>B-cell non-Hodgkin lymphoma-2-associated X protein</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>blood chemistry</topic><topic>Dietary Proteins - administration & dosage</topic><topic>disease prevention</topic><topic>disease severity</topic><topic>epidermal growth factor</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>isoflavones</topic><topic>Isoflavones - administration & dosage</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>men</topic><topic>milk proteins</topic><topic>Milk Proteins - administration & dosage</topic><topic>Neoplasm Staging</topic><topic>Nephrology. Urinary tract diseases</topic><topic>proliferating cell nuclear antigen</topic><topic>Proliferating Cell Nuclear Antigen - metabolism</topic><topic>prostate specific antigen</topic><topic>Prostate-Specific Antigen - metabolism</topic><topic>prostatic neoplasms</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - prevention & control</topic><topic>protein isolates</topic><topic>protein synthesis</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><topic>receptors</topic><topic>risk assessment</topic><topic>soy protein</topic><topic>Soybean Proteins - administration & dosage</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamilton-Reeves, J.M</creatorcontrib><creatorcontrib>Rebello, S.A</creatorcontrib><creatorcontrib>Thomas, W</creatorcontrib><creatorcontrib>Kurzer, M.S</creatorcontrib><creatorcontrib>Slaton, J.W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition and cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamilton-Reeves, J.M</au><au>Rebello, S.A</au><au>Thomas, W</au><au>Kurzer, M.S</au><au>Slaton, J.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer</atitle><jtitle>Nutrition and cancer</jtitle><addtitle>Nutr Cancer</addtitle><date>2008-01</date><risdate>2008</risdate><volume>60</volume><issue>1</issue><spage>7</spage><epage>13</epage><pages>7-13</pages><issn>0163-5581</issn><eissn>1532-7914</eissn><coden>NUCADQ</coden><abstract>Fifty-eight men at high risk of prostate cancer or with low-grade prostate cancer were randomly assigned to consume 1 of 3 protein isolates containing 40 g protein: 1) soy protein (SPI+, 107 mg isoflavones/d); 2) alcohol-washed soy protein (SPI-, <6 mg isoflavones/d); or 3) milk protein (MPI). Proliferating cell nuclear antigen (PCNA), epidermal growth factor receptor, B-cell non-Hodgkin lymphoma-2 (Bcl-2), and Bcl-2-associated X protein (Bax) were assessed in baseline and ending prostate biopsy cores. Serum collected at 0, 3, and 6 mo was analyzed for total and free prostate specific antigen (PSA). Consumption of SPI+ did not alter any of the prostate cancer tumor markers. Bax expression decreased from baseline in the SPI- group, resulting in lower Bax expression than the MPI group. PCNA expression also decreased from baseline in the SPI- group, but this was not different from the other 2 groups. PSA did not differ among the groups at 3 or 6 mo. Interestingly, a lower rate of prostate cancer developed in the soy groups compared to the milk group (P = 0.01). These data suggest that 6-mo SPI+ consumption does not alter prostate tissue biomarkers, SPI- consumption exerts mixed effects, and less prostate cancer is detected after 6 mo of soy consumption regardless of isoflavone content.</abstract><cop>Philadelphia, PA</cop><pub>Taylor & Francis Group</pub><pmid>18444130</pmid><doi>10.1080/01635580701586770</doi><tpages>7</tpages></addata></record> |
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| subjects | adults Aged animal proteins Animals B-cell non-Hodgkin lymphoma-2 X protein B-cell non-Hodgkin lymphoma-2-associated X protein bcl-2-Associated X Protein - metabolism Biological and medical sciences biomarkers Biomarkers - analysis Biomarkers - blood blood chemistry Dietary Proteins - administration & dosage disease prevention disease severity epidermal growth factor Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans isoflavones Isoflavones - administration & dosage Male Male genital diseases Medical sciences men milk proteins Milk Proteins - administration & dosage Neoplasm Staging Nephrology. Urinary tract diseases proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism prostate specific antigen Prostate-Specific Antigen - metabolism prostatic neoplasms Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - prevention & control protein isolates protein synthesis Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor, Epidermal Growth Factor - metabolism receptors risk assessment soy protein Soybean Proteins - administration & dosage Time Factors Tumors Tumors of the urinary system Urinary tract. Prostate gland Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer |
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