Swinging Effect of Salicylic Acid on the Accumulation of Polyhydroxyalkanoic Acid (PHA) in Pseudomonas aeruginosa BM114 Synthesizing Both MCL- and SCL-PHA

A bacterium, Pseudomonas aeruginosa BM114, capable of accumulating a blend of medium-chain-length (MCL)- and short-chain-length (SCL)-polyhydroxyalkanoic acid (PHA), was isolated. Salicylic acid (SA), without being metabolized, was found to specifically inhibit only the accumulation of MCL-PHA witho...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2007-12, Vol.17 (12), p.2018-2026
Hauptverfasser:	Rho, J.K. (Gyeongsang National University, Jinju, Republic of Korea), Choi, M.H. (Gyeongsang National University, Jinju, Republic of Korea), Shim, J.H. (Gyeongsang National University, Jinju, Republic of Korea), Lee, S.Y. (Gyeongsang National University, Jinju, Republic of Korea), Woo, M.J. (Gyeongsang National University, Jinju, Republic of Korea), Ko, B.S. (University of Ulsan, Ulsan, Republic of Korea), Chi, K.W. (University of Ulsan, Ulsan, Republic of Korea), Yoon, S.C. (Gyeongsang National University, Jinju, Republic of Korea), E-mail: scyoon@gnu.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE SALICYLIQUE ACIDO SALICILICO Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology PHA accumulation inhibitor polyhydroxyalkanoic acid SALICYLIC ACIDS SCL-PHA accumulation stimulator
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Beschreibung
Zusammenfassung:	A bacterium, Pseudomonas aeruginosa BM114, capable of accumulating a blend of medium-chain-length (MCL)- and short-chain-length (SCL)-polyhydroxyalkanoic acid (PHA), was isolated. Salicylic acid (SA), without being metabolized, was found to specifically inhibit only the accumulation of MCL-PHA without affecting cell growth. An addition of 20 mM SA selectively inhibited the accumulation of MCL-PHA in decanoate-grown cells by 83% of the control content in one-step cultivation, where overall PHA accumulation was inhibited by only ~11%.
ISSN:	1017-7825