Cutaneous Thrombosis, Cerebrovascular Thrombosis, and Lupus Anticoagulant—the Sneddon Syndrome

Ten patients with circulating lupus anticoagulant who presented with cutaneous vascular disease and Cerebrovascular disease are presented. Cutaneous manifestations were gangrene, thrombophlebitis, ulcers, and livedo reticularis. All 10 patients had cerebral infarction. The relationship between the cerebral and cutaneous vascular changes and the presence of lupus anticoagulant is supported by a common noninflammatory vascular thrombosis histologically in these patients and by the presence of similar pathologic and clinical findings in patients with the lupus anticoagulant syndrome.