Isolation and Expression of Human Cytokine Synthesis Inhibitory Factor cDNA Clones: Homology to Epstein-Barr Virus Open Reading Frame BCRFI
We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1991-02, Vol.88 (4), p.1172-1176 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Vieira, P. de Waal-Malefyt, R. M.-N. Dang Johnson, K. E. Kastelein, R. Fiorention, D. F. de Vries, J. E. M.-G. Roncarolo Mosmann, T. R. Moore, K. W. |
| description | We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities. |
| doi_str_mv | 10.1073/pnas.88.4.1172 |
| format | Article |
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Dang ; Johnson, K. E. ; Kastelein, R. ; Fiorention, D. F. ; de Vries, J. E. ; M.-G. Roncarolo ; Mosmann, T. R. ; Moore, K. W.</creator><creatorcontrib>Vieira, P. ; de Waal-Malefyt, R. ; M.-N. Dang ; Johnson, K. E. ; Kastelein, R. ; Fiorention, D. F. ; de Vries, J. E. ; M.-G. Roncarolo ; Mosmann, T. R. ; Moore, K. W.</creatorcontrib><description>We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.88.4.1172</identifier><identifier>PMID: 1847510</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550201 - Biochemistry- Tracer Techniques ; AMINO ACID SEQUENCE ; AMINO ACIDS ; Analysis of the immune response. Humoral and cellular immunity ; ANIMAL CELLS ; ANIMALS ; ANTIGENS ; B lymphocytes ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOSYNTHESIS ; CARBOXYLIC ACIDS ; Cell Line ; Cell lines ; Cloning, Molecular ; Complementary DNA ; CONNECTIVE TISSUE CELLS ; COS cells ; Cytokines ; DAYS LIVING RADIOISOTOPES ; DNA ; DNA - genetics ; DNA - isolation & purification ; DNA SEQUENCING ; DRUGS ; EVEN-ODD NUCLEI ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; genes ; Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors ; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis ; GROWTH FACTORS ; Herpesvirus 4, Human - genetics ; Humans ; Immunobiology ; IMMUNOLOGY ; INHIBITION ; Interferon-gamma - antagonists & inhibitors ; Interferon-gamma - biosynthesis ; Interleukin-10 ; Interleukins - genetics ; Interleukins - pharmacology ; ISOTOPES ; Leukocytes, Mononuclear - immunology ; LIGHT NUCLEI ; LIPOTROPIC FACTORS ; LYMPHOKINES ; Lymphokines, interleukins ( function, expression) ; MAMMALS ; MAST CELLS ; Messenger RNA ; METHIONINE ; MICE ; MITOGENS ; Molecular Sequence Data ; MOLECULAR STRUCTURE ; NUCLEI ; NUCLEIC ACIDS ; Open Reading Frames ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; Polymerase Chain Reaction ; PROTEINS ; RADIOISOTOPES ; RECOMBINANT DNA ; Recombinant Proteins - pharmacology ; Regulatory factors and their cellular receptors ; RNA ; RNA, Messenger - genetics ; RODENTS ; Sequence Homology, Nucleic Acid ; SOMATIC CELLS ; STRUCTURAL CHEMICAL ANALYSIS ; SULFUR 35 ; SULFUR ISOTOPES ; SYNTHESIS ; T lymphocytes ; Transfection ; VERTEBRATES</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1991-02, Vol.88 (4), p.1172-1176</ispartof><rights>Copyright 1991 The National Academy of Sciences of the United States of America</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-a08216df05767238674922e84689b83ed1655f8b7e870c64bdccf027c892525f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/88/4.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2355956$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2355956$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19828808$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1847510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6203574$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Vieira, P.</creatorcontrib><creatorcontrib>de Waal-Malefyt, R.</creatorcontrib><creatorcontrib>M.-N. Dang</creatorcontrib><creatorcontrib>Johnson, K. E.</creatorcontrib><creatorcontrib>Kastelein, R.</creatorcontrib><creatorcontrib>Fiorention, D. F.</creatorcontrib><creatorcontrib>de Vries, J. E.</creatorcontrib><creatorcontrib>M.-G. Roncarolo</creatorcontrib><creatorcontrib>Mosmann, T. R.</creatorcontrib><creatorcontrib>Moore, K. W.</creatorcontrib><title>Isolation and Expression of Human Cytokine Synthesis Inhibitory Factor cDNA Clones: Homology to Epstein-Barr Virus Open Reading Frame BCRFI</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>AMINO ACID SEQUENCE</subject><subject>AMINO ACIDS</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>ANTIGENS</subject><subject>B lymphocytes</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOSYNTHESIS</subject><subject>CARBOXYLIC ACIDS</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>COS cells</subject><subject>Cytokines</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>DNA SEQUENCING</subject><subject>DRUGS</subject><subject>EVEN-ODD NUCLEI</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>genes</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis</subject><subject>GROWTH FACTORS</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>IMMUNOLOGY</subject><subject>INHIBITION</subject><subject>Interferon-gamma - antagonists & inhibitors</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-10</subject><subject>Interleukins - genetics</subject><subject>Interleukins - pharmacology</subject><subject>ISOTOPES</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>LIGHT NUCLEI</subject><subject>LIPOTROPIC FACTORS</subject><subject>LYMPHOKINES</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>MAMMALS</subject><subject>MAST CELLS</subject><subject>Messenger RNA</subject><subject>METHIONINE</subject><subject>MICE</subject><subject>MITOGENS</subject><subject>Molecular Sequence Data</subject><subject>MOLECULAR STRUCTURE</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>Open Reading Frames</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>Polymerase Chain Reaction</subject><subject>PROTEINS</subject><subject>RADIOISOTOPES</subject><subject>RECOMBINANT DNA</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Regulatory factors and their cellular receptors</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RODENTS</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>SOMATIC CELLS</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>SULFUR 35</subject><subject>SULFUR ISOTOPES</subject><subject>SYNTHESIS</subject><subject>T lymphocytes</subject><subject>Transfection</subject><subject>VERTEBRATES</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuP0zAUhSMEGsrAlhVIFhLsUmzHryA2M6WllUaMNDy2lus4rYfEDraDJr-BP02qlk6RkFhdWec7917bJ8ueIzhFkBdvO6fiVIgpmSLE8YNsgmCJckZK-DCbQIh5Lggmj7MnMd5CCEsq4Fl2hgThFMFJ9msVfaOS9Q4oV4H5XRdMjLujr8Gyb5UDsyH579YZ8HlwaWuijWDltnZtkw8DWCg9VqA_fLoAs8Y7E9-BpW994zcDSB7Mu5iMdfmlCgF8s6GP4LozDtwYVVm3AYugWgMuZzeL1dPsUa2aaJ4d6nn2dTH_MlvmV9cfV7OLq1yzgqVcQYERq2pIOeO4EIyTEmMjCBPlWhSmQozSWqy5ERxqRtaV1vX4EFqUmGJaF-fZ-33frl-3ptLGpaAa2QXbqjBIr6z8W3F2Kzf-p6Sw5OVof7W3-5isjNomo7faO2d0kgzDgnIyQm8OM4L_0ZuYZGujNk2jnPF9lAISwlkB_wsiKmjJIB7B6R7UwccYTH1cGEG5i4LcRUEKIYncRWE0vDy95j2-__tRf33QVdSqqYNy2sZ7rBRYCChONtz1_yMf58i6b5pk7tLJwH-Co_5ir9_GMTJHABeUlpQVvwHZa93I</recordid><startdate>19910215</startdate><enddate>19910215</enddate><creator>Vieira, P.</creator><creator>de Waal-Malefyt, R.</creator><creator>M.-N. 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W.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T3</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19910215</creationdate><title>Isolation and Expression of Human Cytokine Synthesis Inhibitory Factor cDNA Clones: Homology to Epstein-Barr Virus Open Reading Frame BCRFI</title><author>Vieira, P. ; de Waal-Malefyt, R. ; M.-N. Dang ; Johnson, K. E. ; Kastelein, R. ; Fiorention, D. F. ; de Vries, J. E. ; M.-G. Roncarolo ; Mosmann, T. R. ; Moore, K. 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Humoral and cellular immunity</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>ANTIGENS</topic><topic>B lymphocytes</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOSYNTHESIS</topic><topic>CARBOXYLIC ACIDS</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>COS cells</topic><topic>Cytokines</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>DNA SEQUENCING</topic><topic>DRUGS</topic><topic>EVEN-ODD NUCLEI</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>genes</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis</topic><topic>GROWTH FACTORS</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>IMMUNOLOGY</topic><topic>INHIBITION</topic><topic>Interferon-gamma - antagonists & inhibitors</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-10</topic><topic>Interleukins - genetics</topic><topic>Interleukins - pharmacology</topic><topic>ISOTOPES</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>LIGHT NUCLEI</topic><topic>LIPOTROPIC FACTORS</topic><topic>LYMPHOKINES</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>MAMMALS</topic><topic>MAST CELLS</topic><topic>Messenger RNA</topic><topic>METHIONINE</topic><topic>MICE</topic><topic>MITOGENS</topic><topic>Molecular Sequence Data</topic><topic>MOLECULAR STRUCTURE</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>Open Reading Frames</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>Polymerase Chain Reaction</topic><topic>PROTEINS</topic><topic>RADIOISOTOPES</topic><topic>RECOMBINANT DNA</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Regulatory factors and their cellular receptors</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>RODENTS</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>SOMATIC CELLS</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>SULFUR 35</topic><topic>SULFUR ISOTOPES</topic><topic>SYNTHESIS</topic><topic>T lymphocytes</topic><topic>Transfection</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vieira, P.</creatorcontrib><creatorcontrib>de Waal-Malefyt, R.</creatorcontrib><creatorcontrib>M.-N. Dang</creatorcontrib><creatorcontrib>Johnson, K. E.</creatorcontrib><creatorcontrib>Kastelein, R.</creatorcontrib><creatorcontrib>Fiorention, D. F.</creatorcontrib><creatorcontrib>de Vries, J. E.</creatorcontrib><creatorcontrib>M.-G. Roncarolo</creatorcontrib><creatorcontrib>Mosmann, T. R.</creatorcontrib><creatorcontrib>Moore, K. 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Dang</au><au>Johnson, K. E.</au><au>Kastelein, R.</au><au>Fiorention, D. F.</au><au>de Vries, J. E.</au><au>M.-G. Roncarolo</au><au>Mosmann, T. R.</au><au>Moore, K. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and Expression of Human Cytokine Synthesis Inhibitory Factor cDNA Clones: Homology to Epstein-Barr Virus Open Reading Frame BCRFI</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1991-02-15</date><risdate>1991</risdate><volume>88</volume><issue>4</issue><spage>1172</spage><epage>1176</epage><pages>1172-1176</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>1847510</pmid><doi>10.1073/pnas.88.4.1172</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1991-02, Vol.88 (4), p.1172-1176 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_19828808 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550201 - Biochemistry- Tracer Techniques AMINO ACID SEQUENCE AMINO ACIDS Analysis of the immune response. Humoral and cellular immunity ANIMAL CELLS ANIMALS ANTIGENS B lymphocytes BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOSYNTHESIS CARBOXYLIC ACIDS Cell Line Cell lines Cloning, Molecular Complementary DNA CONNECTIVE TISSUE CELLS COS cells Cytokines DAYS LIVING RADIOISOTOPES DNA DNA - genetics DNA - isolation & purification DNA SEQUENCING DRUGS EVEN-ODD NUCLEI Fundamental and applied biological sciences. Psychology Fundamental immunology genes Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis GROWTH FACTORS Herpesvirus 4, Human - genetics Humans Immunobiology IMMUNOLOGY INHIBITION Interferon-gamma - antagonists & inhibitors Interferon-gamma - biosynthesis Interleukin-10 Interleukins - genetics Interleukins - pharmacology ISOTOPES Leukocytes, Mononuclear - immunology LIGHT NUCLEI LIPOTROPIC FACTORS LYMPHOKINES Lymphokines, interleukins ( function, expression) MAMMALS MAST CELLS Messenger RNA METHIONINE MICE MITOGENS Molecular Sequence Data MOLECULAR STRUCTURE NUCLEI NUCLEIC ACIDS Open Reading Frames ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS Polymerase Chain Reaction PROTEINS RADIOISOTOPES RECOMBINANT DNA Recombinant Proteins - pharmacology Regulatory factors and their cellular receptors RNA RNA, Messenger - genetics RODENTS Sequence Homology, Nucleic Acid SOMATIC CELLS STRUCTURAL CHEMICAL ANALYSIS SULFUR 35 SULFUR ISOTOPES SYNTHESIS T lymphocytes Transfection VERTEBRATES |
| title | Isolation and Expression of Human Cytokine Synthesis Inhibitory Factor cDNA Clones: Homology to Epstein-Barr Virus Open Reading Frame BCRFI |
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