Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth Factor β1 in Cultured Uterine Epithelial Cells

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor β 1 (TGF-β 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-04, Vol.88 (8), p.3412-3415
Hauptverfasser:	Rotello, Rocco J., Lieberman, Rita C., Purchio, Anthony F., Gerschenson, Lazaro E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Cell culture techniques Cell death Cell growth Cell lines Cell physiology Cells Cultured cells DNA Epithelial cells Fundamental and applied biological sciences. Psychology Gels Molecular and cellular biology Responses to growth factors, tumor promotors, other factors
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Zusammenfassung:	Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor β 1 (TGF-β 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
ISSN:	0027-8424 1091-6490