Enantiomeric Separation of Substituted Quinuclidines and Aza-Norbornanes By HPLC Using an Acetylated β-Cyclodextrin Bonded Stationary Phase

Enantiomeric Separation of Substituted Quinuclidines and Aza-Norbornanes By HPLC Using an Acetylated β-Cyclodextrin Bonded Stationary Phase

A method for the HPLC enantiomeric separation of substituted azabicycles (quinuclidines and aza-norbornanes) has been developed, after borane complexation with borane-THF, using an acetylated β-cyclodextrin column. the procedure is relatively simple and has been applied to the determination of the e...

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Veröffentlicht in:Journal of liquid chromatography 1991-01, Vol.14 (2), p.287-295
Hauptverfasser: Barnaby, Robert J., Mac Leod, Angus M.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:A method for the HPLC enantiomeric separation of substituted azabicycles (quinuclidines and aza-norbornanes) has been developed, after borane complexation with borane-THF, using an acetylated β-cyclodextrin column. the procedure is relatively simple and has been applied to the determination of the enantiomeric purity of several synthetic compounds of potential pharmaceutical interest.
ISSN:0148-3919
2331-0413
DOI:10.1080/01483919108049615