Solid-liquid phase transfer catalysis without solvent: An improvement for chiral Michael addition of N-acetylaminomalonate to chalcone

Solid-liquid phase transfer catalysis without solvent: An improvement for chiral Michael addition of N-acetylaminomalonate to chalcone

Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes chiral Michael addition when the reaction is achieved in presence of quaternary salts derived from (+) or (−) N-methyl ephedrine. Enantiomeric excesses are significantly increased by “omitting” the organic solvent...

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Veröffentlicht in:Tetrahedron letters 1989, Vol.30 (3), p.333-336
Hauptverfasser: Loupy, André, Sansoulet, Jean, Zaparucha, Anne, Merienne, Claude
Format: Artikel
Sprache:eng
Schlagworte:
Chemical reactivity
Chemistry
Exact sciences and technology
Organic chemistry
Reactivity and mechanisms
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Zusammenfassung:Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes chiral Michael addition when the reaction is achieved in presence of quaternary salts derived from (+) or (−) N-methyl ephedrine. Enantiomeric excesses are significantly increased by “omitting” the organic solvent during the reaction. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)95194-3