Influence of pH Value on Aggregation of Hematoporphyrin Derivates at High Concentrations Measured by Photoacoustic Spectroscopy

Hematoporhyrin derivate (HPD) is used as photosensitizer for the photodynamic therapy (PDT) of cancer. The influence of pH value and concentration of a HPD solution on the protonation and aggregation behaviour is discussed in this study with the help of results from different spectroscopic methods (...

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Veröffentlicht in:	Instrumentation science & technology 1999-09, Vol.27 (4), p.305-310
Hauptverfasser:	Christ, A., Szurkowski, J., Cobet, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences General pharmacology Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Hematoporhyrin derivate (HPD) is used as photosensitizer for the photodynamic therapy (PDT) of cancer. The influence of pH value and concentration of a HPD solution on the protonation and aggregation behaviour is discussed in this study with the help of results from different spectroscopic methods (absorption, fluorescence and photoacoustic spectroscopy).
ISSN:	1073-9149 1525-6030
DOI:	10.1080/10739149908085864